OR2J3 Gene
The OR2J3 gene encodes a particular olfactory receptor, a protein that reacts to specific molecules in the nose to trigger a signal in our perception of smell. OR2J3 encodes one of hundreds of different types of olfactory receptors in the nose. Leaf alcohol (cis-3-hexen-1-ol) — and other chemicals similar to it — trigger the receptor encoded by OR7D4.
Alleles
People normally have two alleles per gene, one inherited from their mother and one inherited from their father.
Sensitive (Global)
This allele has been widespread globally for tens of thousands of years.
Insensitive (African)
This allele originates from an ancient African mutation that occurred thousands of years ago.
Allele Pairs
It is the combination of a person's pair of gene alleles that influences traits.
| Predictable | Easily Smells Leaf Alcohol | |
| Allele Pair | People with this allele pair tend to be more sensitive to grassy odorants in leaf alcohol than those with one or two "Insensitive" alleles. | |
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| Predictable | Hardly Smells Leaf Alcohol | |
| Allele Pair | People with these allele pairs tend to be less sensitive to grassy odorants in leaf alcohol than those with two "Sensitive" alleles. | |
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Gene Details
The OR2J3 gene is located on chromosome 6 and encodes the protein named "Olfactory receptor 2J3", which influences the reported traits.
| Additional References | OR2J3 |
|---|---|
| Genetics Home Reference by the U.S. National Library of Medicine | OR2J3 |
| Wikipedia | OR2J3 |
| UniProt | O76001 |
| U.S. National Center for Biotechnology Information | 442186 |
PubMed articles
Allele Definitions
| [0] | |
|---|---|
| Sensitive |
G
C
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| Insensitive |
T
A
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| Show Minus Strand |
+
-
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| [0] | rs7766902 | dbSNP SNPedia |
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