ACTN3 Gene
The ACTN3 gene encodes the Alpha-actinin protein which is involved in the composition of skeletal muscle.
Alleles
People normally have two alleles per gene, one inherited from their mother and one inherited from their father.
Off (Eurasian)
This allele originates from an ancient Eurasian mutation that occurred thousands of years ago.
On (Global)
This allele has been widespread globally for tens of thousands of years.
Allele Pairs
It is the combination of a person's pair of gene alleles that influences traits.
| Predictable | Slower Sprinting | |
| Allele Pair | While Olympic sprinters tend to not have this allele pair, the collective influence of many environmental factors, such as training and diet, as well as other genes have a far greater impact on sprinting performance than ACTN3 alone. | |
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| Predictable | Faster Sprinting | |
| Allele Pair | While Olympic sprinters tend to have these allele pairs, the collective influence of many environmental factors, such as training and diet, as well as other genes have a far greater impact on sprinting performance than ACTN3 alone. | |
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Gene Details
The ACTN3 gene is located on chromosome 11 and encodes the protein named "Alpha-actinin-3 (alpha-actin-binding)", which influences the reported traits.
| Additional References | ACTN3 |
|---|---|
| Wikipedia | ACTN3 |
| SNPedia | ACTN3 |
| UniProt | Q08043 |
| U.S. National Center for Biotechnology Information | 89 |
PubMed articles
Allele Definitions
| [0] | |
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| On |
C
G
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| Off |
T
A
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| Show Minus Strand |
+
-
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| [0] | rs1815739 | dbSNP SNPedia |
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